Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture

E Lopez, C Arce, MJ Oset-Gasque, S Canadas… - Free Radical Biology …, 2006 - Elsevier
Cadmium is a toxic agent that it is also an environmental contaminant. Cadmium exposure
may be implicated in some humans disorders related to hyperactivity and increased …

Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

JM Matés, JA Segura, FJ Alonso, J Márquez - Free Radical Biology and …, 2010 - Elsevier
Oxidants have critical functions inside healthy and unhealthy cells. Deregulated cell cycle
and apoptosis, both regulated by oxidative stress, have been described as hallmarks of …

Evaluation of the probes 2′, 7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation

O Myhre, JM Andersen, H Aarnes, F Fonnum - Biochemical pharmacology, 2003 - Elsevier
This study attempts to provide a critical assessment of three different common approaches to
identifying reactive species formed in biological systems: the 2′, 7′-dichlorofluorescin …

Antioxidant enzymes responses to cadmium in radish tissues

AP Vitória, PJ Lea, RA Azevedo - Phytochemistry, 2001 - Elsevier
To investigate the antioxidant responses of radish (Raphanus sativus L.) to cadmium (Cd)
treatment, seedlings of a tolerant variety were grown in increasing concentrations of CdCl2 …

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase …

C Rota, CF Chignell, RP Mason - Free Radical Biology and Medicine, 1999 - Elsevier
The oxidation of 2′-7′-dichlorofluorescin (DCFH) to the fluorescent 2′-7′-
dichlorofluorescein (DCF) by horseradish peroxidase (HRP) was investigated by …

Oxidative DNA damage in metal-induced carcinogenesis

KS Kasprzak - Toxicology of Metals, Volume I, 2023 - taylorfrancis.com
Several metals have been found to be carcinogenic to humans and/or animals (Tables 1
and 2). However, the underlying mechanisms remain unclear. It is believed that neoplastic …

Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium

UR Acharya, M Mishra, J Patro, MK Panda - Reproductive toxicology, 2008 - Elsevier
Cadmium (Cd) is a potential pollutant of the environment. It manifests cyto-toxic effects in
different organs in animals. In the present study, intraperitoneal injection of CdCl2 (1mg/kg …

A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine …

SH Oh, SC Lim - Toxicology and applied pharmacology, 2006 - Elsevier
Although reactive oxygen species (ROS) have been implicated in cadmium (Cd)-induced
hepatotoxicity, the role of ROS in this pathway remains unclear. Therefore, we attempted to …

Assessing nanotoxicity in cells in vitro

JM Hillegass, A Shukla, SA Lathrop… - Wiley …, 2010 - Wiley Online Library
Nanomaterials are commonly defined as particles or fibers of less than 1 µm in diameter. For
these reasons, they may be respirable in humans and have the potential, based upon their …

Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress

W Wätjen, D Beyersmann - Biometals, 2004 - Springer
Cadmium has recently been shown to induce apoptosis in C6 glioma cells via disruption of
the mitochondrial membrane potential and subsequent caspase 9-activation. Here we show …