Born to run: control of transcription elongation by RNA polymerase II
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
Comparative flavivirus-host protein interaction map** reveals mechanisms of dengue and Zika virus pathogenesis
Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …
Histone methylation: a dynamic mark in health, disease and inheritance
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
Starch as a source, starch as a sink: the bifunctional role of starch in carbon allocation
Starch commands a central role in the carbon budget of the majority of plants on earth, and
its biological role changes during development and in response to the environment …
its biological role changes during development and in response to the environment …
A double take on bivalent promoters
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Is H3K4me3 instructive for transcription activation?
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …
modification at the transcription start site of active genes in eukaryotes from yeast to man …
[HTML][HTML] H3K4me3 breadth is linked to cell identity and transcriptional consistency
Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …