Nuclear factor kappa B (NF-κB) is an inducible transcription factor present in neurons and
glia. Recent genetic models identified a role for NF-κB in neuroprotection against various …

African swine fever virus (ASFV) can cause an acutely fatal haemorrhagic fever in domestic
pigs although in its natural hosts, warthogs, bushpigs and the soft tick vector, Ornithodoros …

We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity
target binding. Using a consensus design strategy, we generated combinatorial libraries of …

We describe an efficient way to generate combinatorial libraries of stable, soluble and well-
expressed ankyrin repeat (AR) proteins. Using a combination of sequence and structure …

IκBα regulates the transcription factor NF-κB through the formation of stable IκBα/NF-κB
complexes. Prior to induction, IκBα retains NF-κB in the cytoplasm until the NF-κB activation …

The two-feedback-loop regulatory module of nuclear factor κB (NF-κB) signaling pathway is
modeled by means of ordinary differential equations. The constructed model involves two …

Ankyrin repeat (AR) proteins mediate innumerable protein–protein interactions in virtually all
phyla. This finding suggested the use of AR proteins as designed binding molecules. Based …

Designed ankyrin repeat proteins (DARPins) are a novel class of binding molecules, which
can be selected to recognize specifically a wide variety of target proteins. DARPins were …

Sepsis, a hyperinflammatory response that can result in multiple organ dysfunctions, is a
leading cause of mortality from infection. Here, we show that orphan nuclear receptor Nur77 …

The Drosophila CLOCK (dCLOCK) and CYCLE (CYC)(also referred to as dBMAL1) proteins
are members of the basic helix-loop-helix PAS (PER-ARNT-SIM) superfamily of transcription …