Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in sha** later life disease risk-including susceptibility to …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

The hypothalamus is a central regulator of many behaviors that are essential for survival,
such as temperature regulation, food intake and circadian rhythms. However, the molecular …

Early researchers found that lesions of the ventromedial hypothalamus (VMH) resulted in
hyperphagia and obesity in a variety of species including humans, which led them to …

Significant advancements have been made in the past century regarding the neuronal
control of feeding behavior and energy expenditure. The effects and mechanisms of action …

The transcription factor steroidogenic factor 1 (SF-1) is exclusively expressed in the brain in
the ventral medial hypothalamic nucleus (VMH) and is required for the development of this …

Obesity, diabetes, and other metabolic complications are growing concerns for public health
and could lead to detrimental life-threatening conditions. Neurons whose activities are …

Owing to its complex structure and highly diverse cell populations, the study of hypothalamic
development has historically lagged behind that of other brain regions. However, in recent …

Neuronal control of body energy homeostasis is the key mechanism by which animals and
humans regulate their long-term energy balance. Various hypothalamic neuronal circuits …

The ventromedial hypothalamus (VMH) is a distinct morphological nucleus involved in
feeding, fear, thermoregulation, and sexual activity. It is essentially unknown how VMH …