Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic
and neuropsychiatric disorders. Although years of research indicates that distinct …

In many circumstances alternative courses of action and thoughts have to be inhibited to
allow the emergence of goal-directed behavior. However, this has not been the accepted …

Abstract Muscarinic Designer Receptors Exclusively Activated by Designer Drugs
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …

While signatures of attention have been extensively studied in sensory systems, the neural
sources and computations responsible for top-down control of attention are largely …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Currently there is no general approach for achieving specific optogenetic control of
genetically defined cell types in rats, which provide a powerful experimental system for …

Computational analysis of cellular activity has developed largely independently of modern
transcriptomic cell typology, but integrating these approaches may be essential for full …

This protocol details a subset of assays developed within the touchscreen platform to
measure various aspects of executive function in rodents. Three main procedures are …

Depressed patients show cognitive deficits that may depend on an abnormal reaction to
positive and negative feedback. The precise neurochemical mechanisms responsible for …

Hypocretin (orexin) and dynorphin are neuropeptides with opposing actions on motivated
behavior. Orexin is implicated in states of arousal and reward, whereas dynorphin is …