Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …