The roles of gut microbiota and its metabolites in diabetic nephropathy

H Zhao, CE Yang, T Liu, MX Zhang, Y Niu… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

[HTML][HTML] Mycobacterium abscessus: It's Complex

HFM Abdelaal, ED Chan, L Young, SL Baldwin… - Microorganisms, 2022 - mdpi.com
Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing
abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no …

Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation

Z Zheng, M Zhao, H Shan, D Fang, Z **, J Tang, Z Liu… - Autophagy, 2023 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1) plays an
essential role in immune responses for virus inhibition via inducing the production of type I …

[HTML][HTML] Autophagy: guardian of skin barrier

HJ Kim, J Park, SK Kim, H Park, JE Kim, S Lee - Biomedicines, 2022 - mdpi.com
Autophagy is a major degradation pathway that removes harmful intracellular substances to
maintain homeostasis. Various stressors, such as starvation and oxidative stress, upregulate …

Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways

YJ Kim, EJ Park, SH Lee, P Silwal, JK Kim, JS Yang… - Cell & Bioscience, 2023 - Springer
Background Itaconate, a crucial immunometabolite, plays a critical role in linking immune
and metabolic functions to influence host defense and inflammation. Due to its polar …

Association of gut microbiota with intestinal ischemia/reperfusion injury

J Chen, Y Wang, Y Shi, Y Liu, C Wu… - Frontiers in Cellular and …, 2022 - frontiersin.org
Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical
practice with a high mortality rate. However, there is still a lack of effective prevention and …

DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages

A Banducci-Karp, J **e, SAG Engels, C Sarantaris… - Cells, 2023 - mdpi.com
Damage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane
protein, whose function in the immune response is incompletely understood. Based on …

Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy

G Kilinç, R Boland, MT Heemskerk… - Microbiology …, 2024 - journals.asm.org
Mycobacterium tuberculosis (Mtb) as well as nontuberculous mycobacteria are intracellular
pathogens whose treatment is extensive and increasingly impaired due to the rise of …

TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination

Q Ma, J Yu, L Liu, X Ma, J Zhang, J Zhang… - Cell Death …, 2023 - nature.com
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that is
extensively involved in the autophagy process by interacting with diverse autophagy …

Evaluation and clinical impact of MALDI Biotyper Mycobacteria Library v6. 0 for identification of nontuberculous mycobacteria by MALDI‐TOF mass spectrometry

M Markanović, MJ Makek, G Glodić… - Journal of mass …, 2023 - Wiley Online Library
Major challenges in the identification of non‐tuberculous mycobacteria (NTM) by MALDI‐
TOF MS include protein extraction protocol and updating of the NTM database. The aim of …