Cardiovascular diseases (CVDs) are the leading cause of mortality and therefore pose a
significant threat to human health. Cardiac electrophysiology plays a crucial role in the …

Introduction Automated patch clamp (APC) is now well established as a mature technology
for ion channel drug discovery in academia, biotech and pharma companies, and in contract …

Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal
arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 …

In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and
several mechanisms contributing to cardiorenal protection have been identified. In this …

Aims Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
alterations which promote AF chronification and treatment resistance. Development of novel …

BACKGROUND: Alterations in the buffering of intracellular Ca2+, for which myofilament
proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting …

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality,
imposing an increasing global health burden. Cardiac ion channels (voltage-gated Na V, Ca …

Background: After myocardial infarction, the infarct border zone (BZ) is the dominant source
of life-threatening arrhythmias, where fibrosis and abnormal repolarization create a …

The patch-clamp technique is the gold-standard methodology for analysis of excitable cells.
However, throughput of manual patch-clamp is slow, and high-throughput robotic patch …

Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting develo** countries, where coinfection with other …