Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to
new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is …

While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …

Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This
phenomenon takes place in more than 120 mammalian species, including humans, yet its …

Electroconvulsive therapy (ECT) is an effective therapy for depression, but its cellular effects
on the human brain remain elusive. In rodents, electroconvulsive shocks increase …

In the adult dentate gyrus of the hippocampus there are neuronal stem cells that give rise to
immature neurons and subsequently to mature functional granule neurons. The rate of …

The adult hippocampus generates new granule cells (aGCs) with functional capabilities that
convey unique forms of plasticity to the preexisting circuits. While early differentiation of adult …

Quiescence is a prolonged but reversible state of cell-cycle arrest that is an adaptive feature
of most adult stem cell populations. In the brain, quiescence helps to protect adult neural …

Background The neurogenesis hypothesis is a promising candidate etiologic hypothesis for
depression, and it is associated with electroconvulsive therapy (ECT). However, human in …