Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

Background: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which
may result in silent systemic inflammation and promote neuroinflammation-a relevant …

Introduction Mid‐life dietary patterns are associated with Alzheimer's disease (AD) risk,
although few controlled trials have been conducted. Methods Eighty‐seven participants (age …

Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease
(AD). Many previous studies of brain changes underlying cognitive impairment in T2DM …

Background Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most
common neurodegenerative diseases, and mild cognitive impairment (MCI) is considered a …

Alzheimer's disease involves many neurobiological alterations from molecular to
macroscopic spatial scales, but we currently lack integrative, mechanistic brain models …

Alzheimer's disease is associated with a 20–30% reduction in cerebral blood flow. In the
APP/PS1 mouse model of Alzheimer's disease, inhibiting neutrophil adhesion using an …

Aging in later life engenders numerous changes to the cerebral microvasculature. Such
changes can remain clinically silent but are associated with greater risk for negative health …

Although cerebral blood flow (CBF) alterations are associated with Alzheimer's disease
(AD), CBF patterns across prodromal stages of AD remain unclear. Therefore, we …