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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
R Polak, ET Zhang, CJ Kuo - Nature Reviews Cancer, 2024 - nature.com
The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
The two sides of chromosomal instability: drivers and brakes in cancer
R Hosea, S Hillary, S Naqvi, S Wu… - Signal transduction and …, 2024 - nature.com
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
Aneuploidy as a driver of human cancer
E Sdeor, H Okada, R Saad, T Ben-Yishay… - Nature Genetics, 2024 - nature.com
Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …
development and progression and an important determinant of cancer therapeutic …
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations
The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites
JL Reis-Cunha, SA Pimenta-Carvalho… - Genome …, 2024 - genome.cshlp.org
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually
associated with adaptation to stress conditions. Chromosomal duplication stability is a …
associated with adaptation to stress conditions. Chromosomal duplication stability is a …
An elevated rate of whole-genome duplications in cancers from Black patients
Abstract In the United States, Black individuals have higher rates of cancer mortality than
any other racial group. Here, we examine chromosome copy number changes in cancers …
any other racial group. Here, we examine chromosome copy number changes in cancers …
Aneuploidy in human cancer: new tools and perspectives
Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …
but poorly understood feature of cancer. Here, we describe recent advances in both …