A guide to thymic selection of T cells
KM Ashby, KA Hogquist - Nature Reviews Immunology, 2024 - nature.com
The thymus is an evolutionarily conserved organ that supports the development of T cells.
Not only does the thymic environment support the rearrangement and expression of diverse …
Not only does the thymic environment support the rearrangement and expression of diverse …
T-cell tolerance: central and peripheral
Y **ng, KA Hogquist - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
Somatic recombination of TCR genes in immature thymocytes results in some cells with
useful TCR specificities, but also many with useless or potentially self-reactive specificities …
useful TCR specificities, but also many with useless or potentially self-reactive specificities …
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma
D Wang, R Starr, WC Chang, B Aguilar… - Science translational …, 2020 - science.org
Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor
activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To …
activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To …
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy
It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative
signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher …
signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher …
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
P Waterhouse, JM Penninger, E Timms, A Wakeham… - Science, 1995 - science.org
The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been
controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell …
controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell …
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Y Agata, A Kawasaki, H Nishimura… - International …, 1996 - academic.oup.com
A mAb J43 has been produced against the product of the mouse PD-1 gene, a member of
the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell …
the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell …
Positive and negative selection of T cells
TK Starr, SC Jameson… - Annual review of …, 2003 - annualreviews.org
A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …
that are major histocompatibility complex restricted but tolerant to self-antigens. This …
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
HS Azzam, A Grinberg, K Lui, H Shen… - Journal of Experimental …, 1998 - rupress.org
Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator
of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of …
of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of …
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes
Upregulation of diverse self-antigens that constitute components of the inflammatory
response overlaps spatially and temporally with the emergence of pathogen-derived foreign …
response overlaps spatially and temporally with the emergence of pathogen-derived foreign …
How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion
X Tai, A Indart, M Rojano, J Guo, N Apenes… - Nature …, 2023 - nature.com
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-
stimulatory molecules to either undergo clonal deletion or to differentiate into specialized …
stimulatory molecules to either undergo clonal deletion or to differentiate into specialized …