Background Bone regeneration involves various complex biological processes. Many
experiments have been performed using biomaterials in vivo and in vitro to promote and …

Highlights•Alternative bone regenerative therapeutics are needed.•Ions have been
proposed to regenerate skeletal tissue.•Drug delivery systems have been studied to deliver …

Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their
superior mechanical properties, degradability, and excellent biocompatibility. Consistently …

In this work, nanometric hydroxyapatite was added with mineral traces naturally present in
mammalian bones. It was synthesized by wet chemical precipitation using Ca (OH) 2 …

Bioactive glasses (BGs) are promising bone substitute materials. However, under certain
circumstances BGs such as the well-known 45S5 Bioglass®(composition in wt%: 45.0 SiO 2 …

The periosteum plays a crucial role in both bone development and the healing process of
bone fractures. However, few studies have focused on develo** artificial periosteum due …

Traditional designs and developments of bone biomaterials mostly concentrate on the
positive regulation of osteoblast lineage cells, but often ignore the importance of immune …

Modification of implantable scaffolds with magnesium and zinc for improvement of bone
regeneration is a growing trend in the engineering of biomaterials. The aim of this study was …

Bioceramic/polymer composite systems have gained importance in treating hard tissue
damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D …

Angiogenesis at the fracture site plays crucial roles in the endogenous osteogenesis
process and is a prerequisite for the efficient repair of implant fixed bone defects. To improve …