Ventilator-associated pneumonia, ventilator-associated events, and nosocomial respiratory viral infections on the leeside of the pandemic

M Klompas - Respiratory Care, 2024 - liebertpub.com
The COVID-19 pandemic has had an unprecedented impact on population health and
hospital operations. Over 7 million patients have been hospitalized for COVID-19 thus far in …

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

N Spottiswoode, A Tsitsiklis, VT Chu, HV Phan… - Nature …, 2024 - nature.com
Secondary bacterial pneumonia (2° BP) is associated with significant morbidity following
respiratory viral infection, yet remains incompletely understood. In a prospective cohort of …

Tracheal tube infections in critical care: A narrative review of influencing factors, microbial agents, and mitigation strategies in intensive care unit settings

T Motallebirad, MR Mohammadi, A Jadidi… - SAGE Open …, 2024 - journals.sagepub.com
Tracheal tube infections pose significant challenges in the management of mechanically
ventilated patients in intensive care units. These infections contribute to prolonged intensive …

Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a …

D Mangioni, M Panigada, E Palomba, C Bobbio… - Critical Care, 2023 - Springer
Background No univocal recommendation exists for microbiological diagnosis of ventilator-
associated pneumonia (VAP). Sampling of either proximal or distal respiratory tract likely …

[HTML][HTML] Clinical and microbiological impact of implementing a decision support algorithm through Microbiologic Rapid Diagnosis in critically ill patients: an …

A Rodríguez, F Gómez, C Sarvisé, C Gutiérrez… - Biomedicines, 2023 - mdpi.com
Background: Data on the benefits of rapid microbiological testing on antimicrobial
consumption (AC) and antimicrobial resistance patterns (ARPs) are scarce. We evaluated …

Intensive care unit-acquired infections more common in patients with COVID-19 than with influenza

J Beck-Friis, M Gisslén, S Nilsson, A Lindblom… - Scientific Reports, 2024 - nature.com
Intensive care unit-acquired infections are complicating events in critically ill patients. In this
study we analyzed the incidence, microbiological patterns, and outcome in patients with …

Sobreinfecciones intrahospitalarias y su relación con la mortalidad en pacientes obesos o diabéticos con COVID-19 críticamente enfermos

E Osorio-Rodríguez, M Aldana-Roa… - Acta Colombiana de …, 2024 - Elsevier
Objetivo Analizar las sobreinfecciones intrahospitalarias y su relación con la mortalidad en
pacientes obesos o diabéticos con COVID-19 críticamente enfermos. Diseño Analítico …

SARS-CoV-2 viremia but not respiratory viral load is associated with respiratory complications in patients with severe COVID-19

L Chen, LB Olson, IA Naqvi, BA Sullenger… - BMC Pulmonary …, 2024 - Springer
Background Severe COVID-19 carries a high morbidity and mortality. Previous studies have
shown an association between COVID-19 severity and SARS-CoV-2 viral load (VL). We …

Ventilator-associated pneumonia risk factors in patients with severe COVID-19 in southern Brazil: A retrospective observational study

GDS Dos Santos, SO Reikdal, ME Graf… - Infection, Disease & …, 2025 - Elsevier
Abstract Backgound During the SARS-CoV-2 pandemic, a significant number of critical
patients required ventilatory assistance in health institutions. In this context, Ventilator …

Epigenetic attenuation of interferon signaling drives aging-related improvements in systemic lupus

R Narendra, HV Phan, S Patterson, AL Almonte… - medRxiv, 2025 - medrxiv.org
In the general human population, aging is associated with a rise in systemic inflammation,
primarily involving innate immune pathways related to interferon (IFN), toll-like receptor, and …