Harnessing human papillomavirus' natural tropism to target tumors

RC Kines, JT Schiller - Viruses, 2022 - mdpi.com
Human papillomaviruses (HPV) are small non-enveloped DNA tumor viruses established as
the primary etiological agent for the development of cervical cancer. Decades of research …

Altered glycosylation in progression and management of bladder cancer

M Wilczak, M Surman, M Przybyło - Molecules, 2023 - mdpi.com
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated
573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still …

Malaria biomimetic for tumor targeted drug delivery

J Pihl, TM Clausen, J Zhou, N Krishnan… - acs Nano, 2023 - ACS Publications
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

MØ Agerbæk, SR Bang-Christensen, MH Yang… - Nature …, 2018 - nature.com
Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for
disease monitoring and molecular characterization. Despite the development of many new …

Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate

EE Vidal-Calvo, A Martin-Salazar, S Choudhary… - Nature …, 2024 - nature.com
Molecular similarities between embryonic and malignant cells can be exploited to target
tumors through specific signatures absent in healthy adult tissues. One such embryonic …

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy …

DP Petrylak, R de Wit, KN Chi, A Drakaki… - The Lancet …, 2020 - thelancet.com
Summary Background Ramucirumab—an IgG1 vascular endothelial growth factor receptor 2
antagonist—plus docetaxel was previously reported to improve progression-free survival in …

Divergent biological response to neoadjuvant chemotherapy in muscle-invasive bladder cancer

R Seiler, EA Gibb, NQ Wang, HZ Oo, HM Lam… - Clinical cancer …, 2019 - AACR
Purpose: After cisplatin-based neoadjuvant chemotherapy (NAC), 60% of patients with
muscle-invasive bladder cancer (MIBC) still have residual invasive disease at radical …

[HTML][HTML] Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

L Parhi, J Abed, A Shhadeh, T Alon-Maimon, S Udi… - Cell Reports, 2022 - cell.com
While the existence of an indigenous placental microbiota remains controversial, several
pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium …

[HTML][HTML] Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

X Xu, X Zhou, Z Chen, C Gao, L Zhao, Y Cui - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
Long noncoding RNAs (lncRNAs) play critical roles in tumour progression and metastasis.
Emerging evidence indicates that the lncRNA X inactive-specific transcript (XIST) is …

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

N Al-Nakouzi, CK Wang, HZ Oo, I Nelepcu… - Nature …, 2022 - nature.com
Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR)
pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we …