Highlights•Using acquired somatic mutations as a genetic barcode allows reconstruction of
a stem cell “family tree” of relatedness.•Understanding HSC clonal dynamics is central to …

Identifying true DNA cellular barcodes among polymerase chain reaction and sequencing
errors is challenging. Current tools are restricted in the diversity of barcode types supported …

Cellular barcoding is a lineage-tracing methodology that couples heritable synthetic
barcodes to high-throughput sequencing, enabling the accurate tracing of cell lineages …

Recent advances in high‐throughput genomics have enabled the direct tracking of outputs
from many cell types, greatly accelerating the study of developmental processes and tissue …

Individual hematopoietic stem cells (HSCs) produce different amounts of blood cells upon
transplantation. Taking advantage of the intercellular variation, we developed an …

Embedded viral barcoding in combination with high-throughput sequencing is a powerful
technology with which to track single-cell clones. It can provide clonal-level insights into …

Umbilical cord blood (UCB) provides an alternative source of hematopoietic stem cells
(HSCs) for allogeneic transplantation. Administration of sufficient donor HSCs is critical to …

Clonal tracking methods provide quantitative insights into the cellular output of genetically
labeled progenitor cells across time and cellular compartments. In the context of gene and …

Single-cell lineage tracing permits the labeling of individual cells with a heritable marker to
follow the fate of each cell's progeny. Over the last twenty years, several single-cell lineage …

Motivation Genetic barcodes have been established as an efficient method to trace clonal
progeny of uniquely labeled cells by introducing artificial genetic sequences into the …