The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …

Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the
adaptive immune response. Their subsets and developmental origins have been intensively …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

The divergence of the common dendritic cell progenitor,–(CDP) into the conventional type 1
and type 2 dendritic cell (cDC1 and cDC2, respectively) lineages, is poorly understood …

Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during
immune responses, ranging from initial viral control through the production of type I …

The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2
conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown …

Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …

Developmental origins of dendritic cells (DCs) including conventional DCs (cDCs,
comprising cDC1 and cDC2 subsets) and plasmacytoid DCs (pDCs) remain unclear. We …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …