Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences
are often underestimated. Damage to cellular macromolecules upon excitation light …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Centrosomes are the primary microtubule organizer in eukaryotic cells. In addition to
sha** the intracellular microtubule network and the mitotic spindle, centrosomes are …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Precise regulation of centrosome number is critical for accurate chromosome segregation
and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers …

The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in
other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division,. By contrast …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …