Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

Randomized clinical trials (RCTs) not only are the gold standard for evaluating the efficacy
and effectiveness of psychiatric treatments but also can be valuable in revealing moderators …

There is a longstanding association between substance-use disorders (SUDs) and the
psychological construct of impulsivity. In the first section of this review, personality and …

OBJECTIVE: The authors developed a methodological basis for investigating how risk
factors work together. Better methods are needed for understanding the etiology of …

It is well recognized that different patients respond in different ways to the same medication.
These differences are often greater among members of a population than they are within the …

Objective: In recognition of the increasingly important role of moderators and mediators in
clinical research, clear definitions are sought of the two terms to avoid inconsistent …

OBJECTIVE: This article reviews recent developments in cytokine biology that are relevant
to clinical psychiatry. METHOD: The authors reviewed English-language literature of the last …

Depression is a major cause of disability worldwide, but we know little about the underlying
fundamental biology. Research is hindered by the difficulties of modelling a disorder of …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …