Bladder cancer

L Dyrskjøt, DE Hansel, JA Efstathiou… - Nature reviews Disease …, 2023 - nature.com
Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Recurrence mechanisms of non-muscle-invasive bladder cancer—A clinical perspective

JYC Teoh, AM Kamat, PC Black, P Grivas… - Nature Reviews …, 2022 - nature.com
Non-muscle-invasive bladder cancer (NMIBC) is an early-stage cancer without invasion into
the detrusor muscle layer. Transurethral resection of bladder tumour (TURBT) is a diagnostic …

Construction of self-assembly based tunable absorber: lightweight, hydrophobic and self-cleaning properties

Z Zhou, Q Zhu, Y Liu, Y Zhang, Z Jia, G Wu - Nano-Micro Letters, 2023 - Springer
Although multifunctional aerogels are expected to be used in applications such as portable
electronic devices, it is still a great challenge to confer multifunctionality to aerogels while …

Y chromosome loss in cancer drives growth by evasion of adaptive immunity

HA Abdel-Hafiz, JM Schafer, X Chen, T **ao… - Nature, 2023 - nature.com
Loss of the Y chromosome (LOY) is observed in multiple cancer types, including 10–40% of
bladder cancers,,,,–, but its clinical and biological significance is unknown. Here, using …

FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression

A Okato, T Utsumi, M Ranieri, X Zheng, M Zhou… - The Journal of Clinical …, 2024 - jci.org
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential

K Butler, AR Banday - Journal of Hematology & Oncology, 2023 - Springer
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …

The impact of FGFR3 alterations on the tumor microenvironment and the efficacy of immune checkpoint inhibitors in bladder cancer

K Komura, K Hirosuna, S Tokushige, T Tsu**o… - Molecular Cancer, 2023 - Springer
Background Currently, only limited knowledge is available regarding the phenotypic
association between fibroblast growth factor receptor 3 (FGFR3) alterations and the tumor …

[HTML][HTML] Elevated T-cell exhaustion and urinary tumor DNA levels are associated with Bacillus Calmette-Guérin failure in patients with non–muscle-invasive bladder …

T Strandgaard, SV Lindskrog, I Nordentoft… - European Urology, 2022 - Elsevier
Background The functional status of immune cells in the tumor microenvironment and tumor
characteristics may explain bacillus Calmette-Guérin (BCG) failure in high-risk non–muscle …

Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers

NK Shala, JS Stenehjem, R Babigumira, FC Liu… - British Journal of …, 2023 - nature.com
Background Occupational exposures constitute the second leading cause of urinary bladder
cancer after tobacco smoking. Increased risks have been found in the petroleum industry …

Circulating and urinary tumour DNA in urothelial carcinoma—Upper tract, lower tract and metastatic disease

KM Rose, HL Huelster, JJ Meeks, BM Faltas… - Nature Reviews …, 2023 - nature.com
Precision medicine has transformed the way urothelial carcinoma is managed. However,
current practices are limited by the availability of tissue samples for genomic profiling and …