The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Sorting nexin (SNX) 9 was first discovered as an endocytic accessory protein involved in
clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional …

Programmed cell death is an integral component of Caenorhabditis elegans development.
Genetic and reverse genetic studies in C. elegans have led to the identification of many …

Cells release extracellular vesicles (EVs) that mediate intercellular communication and
repair damaged membranes. Despite the pleiotropic functions of EVs in vitro, their in vivo …

Cell death plays a major role during C. elegans oogenesis, where over half of the oogenic
germ cells die in a process termed physiological apoptosis. How germ cells are selected for …

Primordial germ cells (PGCs) in many species associate intimately with endodermal cells,
but the significance of such interactions is largely unexplored. Here, we show that …

The membrane–cytosol interface is the major locus of control of actin polymerization. At this
interface, phosphoinositides act as second messengers to recruit membrane-binding …

Programmed cell death is critical to the development of diverse animal species from C.
elegans to humans. In C. elegans, the cell death program has three genetically …

Apoptosis is a cellular suicide process that quietly and efficiently eliminates unwanted or
damaged cells. In metazoans, cells that undergo apoptosis are swiftly internalized by …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis. The genetically controlled, autonomously ordered cell death …