Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …

The Boyden chamber assay, originally introduced by Boyden for the analysis of leukocyte
chemotaxis, is based on a chamber of two medium-filled compartments separated by a …

All multicellular animals express receptors for growth factors (GFs) and extracellular matrix
(ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and …

CagA delivered from Helicobacter pylori into gastric epithelial cells undergoes tyrosine
phosphorylation and induces host cell morphological changes. Here we show that CagA …

Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and
tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met …

Tight junctions (TJs) are the most apical cell-cell junctions, and claudins, the recently
identified TJ proteins, are critical for maintaining cell-cell adhesion in epithelial cell sheets …

Epithelial cells undergo tubulogenesis in response to morphogens such as hepatocyte
growth factor (HGF). To organize into tubules, cells must execute a complex series of …

Hepatocyte growth factor (HGF) and its specific c-met receptor constitute a paired signaling
system that plays an important role in renal development and in the maintenance of normal …

The stabilization of endothelial cell (EC) barrier function within newly formed capillaries is a
critical feature of angiogenesis. We examined human lung EC barrier regulation elicited by …