Translation and mRNA stability control
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …
post-transcriptional process that profoundly impact protein production in a cell. While it is …
The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response
BJ Lang, ME Guerrero, TL Prince, Y Okusha… - Archives of …, 2021 - Springer
Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …
Spontaneous helielectric nematic liquid crystals: Electric analog to helimagnets
Recently, a type of ferroelectric nematic fluid has been discovered in liquid crystals in which
the molecular polar nature at molecule level is amplified to macroscopic scales through a …
the molecular polar nature at molecule level is amplified to macroscopic scales through a …
[BOOK][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
Base editor screens for in situ mutational scanning at scale
A fundamental challenge in biology is understanding the molecular details of protein
function. How mutations alter protein activity, regulation, and response to drugs is of critical …
function. How mutations alter protein activity, regulation, and response to drugs is of critical …
Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD
C9ORF72 hexanucleotide repeat expansion is the most common genetic cause of both
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One pathogenic …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One pathogenic …
[HTML][HTML] Translation rates and protein folding
The mRNA coding sequence defines not only the amino acid sequence of the protein, but
also the speed at which the ribosomes move along the mRNA while making the protein. The …
also the speed at which the ribosomes move along the mRNA while making the protein. The …
Codon language embeddings provide strong signals for use in protein engineering
Protein representations from deep language models have yielded state-of-the-art
performance across many tasks in computational protein engineering. In recent years …
performance across many tasks in computational protein engineering. In recent years …
The essential functions of molecular chaperones and folding enzymes in maintaining endoplasmic reticulum homeostasis
It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance
AC Kessler, RJ Maraia - Nucleic Acids Research, 2021 - academic.oup.com
A 1969 report that described biochemical and activity properties of the three eukaryotic RNA
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …