Respiratory syncytial virus (RSV) is amongst the most important pathogenic infections of
childhood and is associated with significant morbidity and mortality. Although there have …

Viral pathogens often induce strong effector CD4+ T cell responses that are best known for
their ability to help B cell and CD8+ T cell responses. However, recent studies have …

Rationale: An exaggerated or persistent inflammatory activation after myocardial infarction
(MI) leads to maladaptive healing and subsequent remodeling of the left ventricle. Foxp3+ …

INTRODUCTION Even with intimate exposure to a virus, some people fail to become
infected. Variable transmission partly depends on the dose and duration of exposure but is …

Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …

Recent years have seen several advances in our understanding of immunity to virus
infection of the lower respiratory tract, including to influenza virus infection. Here, we review …

Type I interferons (IFNs) are important for host defense from viral infections, acting to restrict
viral production in infected cells and to promote antiviral immune responses. However, the …

Respiratory syncytial virus (RSV) infections are a constant public health problem, especially
in infants and older adults. Virtually all children will have been infected with RSV by the age …

Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and
adaptive immune responses. In humans with respiratory virus infections, such as …

Because of its essential role in gas exchange and oxygen delivery, the lung has evolved a
variety of strategies to control inflammation and maintain homeostasis. Invasion of the lung …