The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently
been moved into the center of the spotlight for measuring the mechanical properties of …

Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic
and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to …

Bioengineered hearts, which include single cardiomyocytes, engineered heart tissue, and
chamber-like models, generate various biosignals, such as contractility …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Despite significant progress in human medicine, certain diseases remain challenging to
promptly diagnose and treat. Hence, the imperative lies in the development of more …

Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac
compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial …

Cardiomyocytes are the motor units that drive the contraction and relaxation of the heart.
Traditionally, testing of drugs for cardiotoxic effects has relied on primary cardiomyocytes …

Mechanical forces provide critical biological signals to cells during healthy and aberrant
organ development as well as during disease processes in adults. Within the …