Cannabinoids, including the two main phytocannabinoids Δ 9-tetrahydrocannabinol (THC)
and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for …

Sleep is regulated by several brain structures, neurotransmitters and neuromodulators.
Endocannabinoids (eCBs) are a group of lipids with modulatory activity in the brain and bind …

ABSTRACT A considerable amount experimental studies have shown that maternal
separation (MS) is associated with adult offspring abnormal behavior and cognition disorder …

The antiallergic potential of Arctium lappa L. was investigated in Sprague–Dawley rats, ICR
mice, and RBL-2H3 cells. Ethanol extract (90%) of A. lappa (ALE, 100 μg/mL) inhibited the …

Cannabis sativa (Marijuana) has a long history as a medicinal plant and Δ9-
tetrahydrocannabinol (Δ9-THC) is the most active component in this plant. Cannabinoids are …

Clinical and preclinical studies suggest that early life stress can increase the risk of
develo** ethanol use disorder later in life. Although the endocannabinoid (eCB) system …

Most of the drugs of abuse affect the brain by interacting with naturally expressed molecular
receptors. Marihuana affects a series of receptors including cannabinoid receptor 1 (CB1R) …

Depression is one of the most frequent causes of disability in the 21st century. Despite the
many preclinical and clinical studies that have addressed this brain disorder, the …

Orexins/hypocretins (OX) and melanin-concentrating hormone (MCH) neurons located in the
lateral hypothalamus seem to modulate different stages of the sleep–wake cycle. OX are …

The sleep-wake cycle is a complex process that includes wake (W), non-rapid-eye-
movement (NREM) and rapid-eye-movement (REM) sleep. Each phase is regulated by …