Prescribed drugs containing nitrogen heterocycles: an overview

MM Heravi, V Zadsirjan - RSC advances, 2020 - pubs.rsc.org
Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

P Dey, A Kundu, A Kumar, M Gupta, BM Lee… - Recent advances in …, 2020 - Elsevier
Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They
are all secondary compounds and collection of miscellaneous elements and biomolecules …

Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

PS Auti, G George, AT Paul - RSC advances, 2020 - pubs.rsc.org
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Metal-mediated and metal-catalyzed reactions under mechanochemical conditions

A Porcheddu, E Colacino, L De Luca, F Delogu - ACS Catalysis, 2020 - ACS Publications
The extraordinary impact of metal-based complexes on synthetic methods is still recognized
nowadays, and attempts are currently undertaken to further extend the use of metal-assisted …

Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective

E Vitaku, DT Smith, JT Njardarson - Journal of medicinal chemistry, 2014 - ACS Publications
Nitrogen heterocycles are among the most significant structural components of
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …

A study in the relationship between supportive work environment and employee retention: Role of organizational commitment and person–organization fit as …

S Naz, C Li, QA Nisar, MAS Khan, N Ahmad… - Sage …, 2020 - journals.sagepub.com
The main aim of the study was to empirically investigate the mediating role of organizational
commitment (OC) and person–organization fit (POF) between the causal relationship of …

Indoles—A promising scaffold for drug development

TV Sravanthi, SL Manju - European Journal of Pharmaceutical Sciences, 2016 - Elsevier
Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

[HTML][HTML] Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

Recent progress in biological activities of indole and indole alkaloids

TP Singh, OM Singh - Mini reviews in medicinal chemistry, 2018 - benthamdirect.com
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …