Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …

Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Parkinson disease (PD) is associated with progressive loss of dopaminergic neurons in the
substantia nigra, as well as with more-widespread neuronal changes that cause complex …

Several biochemical abnormalities have been described in the brains of patients with
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …

Alzheimer's disease (AD) includes etiologically heterogenous disorders characterized by
senile or presenile dementia, extracellular amyloid protein aggregations containing an …

Loss of mitochondrial complex I catalytic activity in the electron transport chain (ETC) is
found in multiple tissues from individuals with sporadic Parkinson's disease (PD) and is a …