Proton therapy–present and future

R Mohan, D Grosshans - Advanced drug delivery reviews, 2017 - Elsevier
In principle, proton therapy offers a substantial clinical advantage over conventional photon
therapy. This is because of the unique depth-dose characteristics of protons, which can be …

Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements

S Her, DA Jaffray, C Allen - Advanced drug delivery reviews, 2017 - Elsevier
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-
ray absorption, synthetic versatility, and unique chemical, electronic and optical properties …

NCCN guidelines insights: head and neck cancers, version 1.2018

AD Colevas, SS Yom, DG Pfister, S Spencer… - Journal of the National …, 2018 - jnccn.org
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment
recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary …

Biological effects in normal cells exposed to FLASH dose rate protons

M Buonanno, V Grilj, DJ Brenner - Radiotherapy and Oncology, 2019 - Elsevier
Background Radiotherapy outcomes are limited by toxicity in the healthy tissues
surrounding the irradiated tumor. Recent pre-clinical studies have shown that irradiations …

Nuclear physics in particle therapy: a review

M Durante, H Paganetti - Reports on Progress in Physics, 2016 - iopscience.iop.org
Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience

T Kamada, H Tsujii, EA Blakely, J Debus… - The Lancet …, 2015 - thelancet.com
Charged particle therapy is generally regarded as cutting-edge technology in oncology.
Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres …

First clinical application of a prompt gamma based in vivo proton range verification system

C Richter, G Pausch, S Barczyk, M Priegnitz… - Radiotherapy and …, 2016 - Elsevier
Background and purpose To improve precision of particle therapy, in vivo range verification
is highly desirable. Methods based on prompt gamma rays emitted during treatment seem …

Charged particle therapy—optimization, challenges and future directions

JS Loeffler, M Durante - Nature reviews Clinical oncology, 2013 - nature.com
The use of charged particle therapy to control tumours non-invasively offers advantages
over conventional radiotherapy. Protons and heavy ions deposit energy far more selectively …

Magnetic hyperthermia and radiation therapy: radiobiological principles and current practice

SV Spirou, M Basini, A Lascialfari, C Sangregorio… - Nanomaterials, 2018 - mdpi.com
Hyperthermia, though by itself generally non-curative for cancer, can significantly increase
the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its …

Prostate cancer, version 2.2014

JL Mohler, PW Kantoff, AJ Armstrong… - Journal of the National …, 2014 - jnccn.org
Prostate cancer has surpassed lung cancer as the most common cancer in men in the
United States. The NCCN Guidelines for Prostate Cancer provide multidisciplinary …