Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Rationale: Emerging evidences have highlighted the critical roles of lncRNAs in human
cancer development. The work sought to assess the biological role and potential underlying …

This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

Chemotherapy and immunotherapy for pancreatic ductal adenocarcinoma (PDAC) have
limited success. One reason for this is thought to be the cancer microenvironment …

Oxidative stress refers to an imbalance between reactive oxygen species (ROS) generation
and body's capability to detoxify the reactive mediators or to fix the relating damage …

Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …

Hypoxia is a common feature of the tumor microenvironment (TME) of nearly all solid tumors,
leading to therapeutic failure. The changes in stiffness of the extracellular matrix (ECM), pH …