Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …

Several potential disease-modifying drugs for Alzheimer's disease (AD) have failed to show
any effect on disease progression in clinical trials, conceivably because the AD subjects are …

Early diagnosis of Alzheimer's disease plays a pivotal role in patient care and clinical trials.
In this study, we have developed a new approach based on 3D deep convolutional neural …

Alzheimer's Disease (AD) is becoming increasingly prevalent across the globe, and various
diagnostic and detection methods have been developed in recent years. Several techniques …

Stress affects cognition in a number of ways, acting rapidly via catecholamines and more
slowly via glucocorticoids. Catecholamine actions involve beta adrenergic receptors and …

▪ Abstract The hippocampus is a target of stress hormones, and it is an especially plastic and
vulnerable region of the brain. It also responds to gonadal, thyroid, and adrenal hormones …

In recent years, patients who are at high risk for develo** Alzheimer's disease (AD) have
become a focus of study. Several research groups have identified these patients, developed …

Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are
related to the risk of future conversion to Alzheimer's disease (AD) in older patients with a …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

Background: The cognitive continuum in the elderly population can be conceptually divided
into those who are functioning normally (control subjects), those with a mild cognitive …