Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA),
which are considered broadly health-promoting. Accordingly, consumption of such fibers …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancer cases, with
more than 850,000 new diagnoses per year globally. Recent trends in the United States …

Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …

Background & Aims Despite recent progress, long-term survival remains low for
hepatocellular carcinoma (HCC). The most effective HCC therapies target the tumor immune …

Background & Aims Carcinogen-induced mouse models of liver cancer are used extensively
to study the pathogenesis of the disease and are critical for validating candidate …

CoNClUSIoNS: This study provides evidence for AA-induced liver cancer with the featured
mutational processes during malignant clonal evolution, laying a solid foundation for the …

Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-
driven antioxidant systems form an integrated network that combats potentially carcinogenic …

Preclinical models of cancer based on the use of human cancer cell lines and mouse
models have enabled discoveries that have been successfully translated into patients. And …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third
leading cause of cancer related mortality with a 10 year survival rate of merely 22–35 …