Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class
with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many …

Water is an indispensable natural resource and is the most vital substance for the existence
of life on earth. However, due to anthropogenic activities, it is being polluted at an alarming …

The place of aspirin in primary prevention remains controversial, with North American and
European organizations issuing contradictory treatment guidelines. More recently, the US …

The benefits of aspirin therapy for the secondary prevention of cardiovascular disease
clearly outweigh the risks of bleeding, and low-dose aspirin is uniformly recommended in …

Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …

During the past 30 years, several developments have occurred in the antiplatelet field,
including the role of aspirin in primary prevention of atherosclerotic cardiovascular disease …

Essential thrombocythemia (ET) is characterized by abnormal megakaryopoiesis and
enhanced thrombotic risk. Once-daily low-dose aspirin is the recommended antithrombotic …

The voluntary withdrawal of Vioxx (rofecoxib) from the market in 2004, as well as the 2005
and 2014 US FDA Advisory Committee meetings about non-steroidal anti-inflammatory …

Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

Inactivation of platelet cyclooxygenase (COX)-1 by low-dose aspirin leads to long-lasting
suppression of thromboxane (TX) A2 production and TXA2-mediated platelet activation and …