The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

During myocardial infarction, infiltrated macrophages have pivotal roles in cardiac
remodeling and delayed M1 toward M2 macrophage phenotype transition is considered one …

Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various
kinases, several of which have been implicated in aberrant fibroblast activation in fibrotic …

In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs)
have also been adopted by healthy individuals to prevent being overweight. Herein, we …

Inflammation is a fundamental response of the immune system whose successful
termination involves the elimination of the invading pathogens, the resolution of …

STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell
cycle, cell survival and immune response. The cross-talk between these signaling pathways …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that
results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in …

Background The hyper-IgE syndrome (or Job's syndrome) is a rare disorder of immunity and
connective tissue characterized by dermatitis, boils, cyst-forming pneumonias, elevated …