Innovative strategies for enhancing topical and transdermal drug delivery

DIJ Morrow, PA McCarron, AD Woolfson… - … Drug Deliv. J, 2007 - benthamopen.com
Historically, the skin was thought to be a simple homogenous barrier. However, it is now
known to be a highly specialised organ, and plays a key role in homeostasis. The protective …

Transdermal iontophoresis

B Priya, T Rashmi, M Bozena - Expert opinion on drug delivery, 2006 - Taylor & Francis
Iontophoresis is a technique used to enhance the transdermal delivery of compounds
through the skin via the application of a small electric current. By the process of …

Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation

F Han, R Yin, X Che, J Yuan, Y Cui, H Yin… - International journal of …, 2012 - Elsevier
Nanostructured lipid carriers (NLC)-based gel was developed as potential topical system for
flurbiprofen (FP) topical delivery. The characterizations of the prepared semisolid …

A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne

A Jain, NK Garg, A Jain, P Kesharwani… - Drug Development …, 2016 - Taylor & Francis
The present study documents the fabrication and characterization of a topically applicable
gel loaded with nanostructured lipid carriers (NLCs) of adapalene (ADA) and vitamin C …

Development of gellan gum containing formulations for transdermal drug delivery: Component evaluation and controlled drug release using temperature responsive …

CA Carmona-Moran, O Zavgorodnya… - International journal of …, 2016 - Elsevier
Enhancing skin permeation is important for development of new transdermal drug delivery
formulations. This is particularly relevant for non-steroidal anti-inflammatory drugs (NSAIDs) …

Mucoadhesive multiparticulate drug delivery systems: An extensive review of patents

S Komati, S Swain, MEB Rao… - Advanced …, 2019 - pmc.ncbi.nlm.nih.gov
Innovations in pharmaceutical research are striving for designing newer drug therapies to
eradicate deadly diseases. Strategies for such inventions always flourish with keys and …

Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos

T Gratieri, GM Gelfuso, RFV Lopez - Química Nova, 2008 - SciELO Brasil
Physicochemical constraints severely limit the number of molecules that can be considered
as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a …

Design and evaluation of topical diclofenac sodium gel using hot melt extrusion technology as a continuous manufacturing process with Kolliphor® P407

J Pawar, R Narkhede, P Amin, V Tawde - AAPS PharmSciTech, 2017 - Springer
The aim of the present context was to develop and evaluate a Kolliphor® P407-based
transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; …

Improvement of transdermal delivery of sumatriptan succinate using a novel self-dissolving microneedle array fabricated from sodium hyaluronate in rats

D Wu, Y Quan, F Kamiyama, K Kusamori… - Biological and …, 2015 - jstage.jst.go.jp
The purpose of the present study was to develop an alternative transdermal formulation
containing sumatriptan succinate (SS) for the treatment of migraine. Novel self-dissolving SS …

Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen

NS Barakat - AAPS PharmSciTech, 2010 - Springer
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect
in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to …