Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Background & Aims We have shown that reciprocally activated rat sarcoma (RAS)/mitogen-
activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus …

Abstract Current US Food and Drug Administration-approved chimeric antigen receptor
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …

AT cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ,
γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative …

Chimeric antigen receptor (CAR) T cell therapy has transformed the care of refractory B cell
malignancies and holds tremendous promise for many aggressive tumors. Despite …

CD4+ T cells are vital for host defense and immune regulation. However, the fundamental
role of CD4 itself remains enigmatic. We report seven patients aged 5–61 years from five …

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of
the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck …

Nipah virus (NiV) is an emerging highly lethal zoonotic disease that, like SARS-CoV-2, can
be transmitted via respiratory droplets. Single-injection vaccines that rapidly control NiV …

Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas,
leukemias, and multiple myeloma in which the tumor cells express high amounts of target …