RNA-targeting and gene editing therapies for transthyretin amyloidosis
A Aimo, V Castiglione, C Rapezzi, M Franzini… - Nature Reviews …, 2022 - nature.com
Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver and secreted into
the plasma. TTR molecules can misfold and form amyloid fibrils in the heart and peripheral …
the plasma. TTR molecules can misfold and form amyloid fibrils in the heart and peripheral …
Critical Comparison of Documents From Scientific Societies on Cardiac Amyloidosis: JACC State-of-the-Art Review
C Rapezzi, A Aimo, M Serenelli, A Barison… - Journal of the American …, 2022 - jacc.org
Over the last year, 5 national or international scientific societies have issued documents
regarding cardiac amyloidosis (CA) to highlight the emerging clinical science, raise …
regarding cardiac amyloidosis (CA) to highlight the emerging clinical science, raise …
JCS 2020 guideline on diagnosis and treatment of cardiac amyloidosis
H Kitaoka, C Izumi, Y Izumiya, T Inomata, M Ueda… - Circulation …, 2020 - jstage.jst.go.jp
[CQ1] What is the role of 99 mTc-PYP scintigraphy (bone scintigraphy) in clinical practice for
CA?∙∙∙∙∙∙ 1655 [CQ2] The role of endomyocardial biopsy. Which site is appropriate for biopsy …
CA?∙∙∙∙∙∙ 1655 [CQ2] The role of endomyocardial biopsy. Which site is appropriate for biopsy …
Carpal tunnel syndrome (Primer)
Carpal tunnel syndrome (CTS) is the most common nerve entrapment disorder worldwide.
The epidemiology and risk factors, including family burden, for develo** CTS are multi …
The epidemiology and risk factors, including family burden, for develo** CTS are multi …
European heart rhythm association (EHRA)/heart rhythm society (HRS)/Asia pacific heart rhythm society (APHRS)/latin American heart rhythm society (LAHRS) expert …
Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …
Atrial amyloidosis: mechanisms and clinical manifestations
G Vergaro, A Aimo, C Rapezzi… - European Journal of …, 2022 - Wiley Online Library
Cardiac amyloidosis (CA) is now recognized as an important cause of heart failure.
Increased wall thickness and diastolic dysfunction of the left ventricle are the most easily …
Increased wall thickness and diastolic dysfunction of the left ventricle are the most easily …
Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis
Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an increasingly diagnosed
disease. Echocardiography is widely utilized, but studies to confirm the value of …
disease. Echocardiography is widely utilized, but studies to confirm the value of …
Low sensitivity of bone scintigraphy in detecting Phe64Leu mutation-related transthyretin cardiac amyloidosis
Objectives The aim of this study was to assess the diagnostic accuracy of bone scintigraphy
in a large multicenter cohort of patients with cardiac amyloidotic involvement and Phe64Leu …
in a large multicenter cohort of patients with cardiac amyloidotic involvement and Phe64Leu …
Diagnostic performance of imaging investigations in detecting and differentiating cardiac amyloidosis: a systematic review and meta‐analysis
J Brownrigg, M Lorenzini, M Lumley… - ESC heart failure, 2019 - Wiley Online Library
Aims The study aims to systematically assess the diagnostic performance of cardiac
magnetic resonance (CMR) and nuclear scintigraphy (index tests) for the diagnosis and …
magnetic resonance (CMR) and nuclear scintigraphy (index tests) for the diagnosis and …
Low QRS voltages in cardiac amyloidosis: clinical correlates and prognostic value
Abstract Background Low QRS voltages (LQRSVs) are a common electrocardiographic
feature in patients with light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) …
feature in patients with light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) …