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Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a significant global
health challenge, further compounded by the issue of antimicrobial resistance (AMR). AMR …
health challenge, further compounded by the issue of antimicrobial resistance (AMR). AMR …
Alternative therapeutics to control antimicrobial resistance: a general perspective
Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review
article, we examine the limitations of traditional therapeutic methods and the emerging role …
article, we examine the limitations of traditional therapeutic methods and the emerging role …
Mycobacterial HelD connects RNA polymerase recycling with transcription initiation
Mycobacterial HelD is a transcription factor that recycles stalled RNAP by dissociating it from
nucleic acids and, if present, from the antibiotic rifampicin. The rescued RNAP, however …
nucleic acids and, if present, from the antibiotic rifampicin. The rescued RNAP, however …
MoaB2, a newly identified transcription factor, binds to σA in Mycobacterium smegmatis
In mycobacteria, σA is the primary sigma factor. This essential protein binds to RNA
polymerase (RNAP) and mediates transcription initiation of housekee** genes. Our …
polymerase (RNAP) and mediates transcription initiation of housekee** genes. Our …
Nα‐Aroyl‐N‐Aryl‐Phenylalanine Amides: A Promising Class of Antimycobacterial Agents Targeting the RNA Polymerase
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the leading cause of
death from a bacterium in the world. The global prevalence of clinically relevant infections …
death from a bacterium in the world. The global prevalence of clinically relevant infections …
In silico virtual screening for the identification of novel inhibitors against dihydrodipicolinate reductase (DapB) of Mycobacterium tuberculosis, a key enzyme of …
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) is one of the most
devastating infectious diseases afflicting a large number of human lives. In spite of the …
devastating infectious diseases afflicting a large number of human lives. In spite of the …
Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis
The limitations of TB treatment are the long duration and immune-dampening effects of anti-
tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence …
tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence …
The heparin-binding hemagglutinin protein of Mycobacterium tuberculosis is a nucleoid-associated protein
Nucleoid-associated proteins (NAPs) regulate multiple cellular processes such as gene
expression, virulence, and dormancy throughout bacterial species. NAPs help in the survival …
expression, virulence, and dormancy throughout bacterial species. NAPs help in the survival …
HelD is a Global Transcription Factor Enhancing Gene Expression in Rapidly Growing Mycobacteria
HelD protein, also named HelR (encoded by MSMEG_2174 in Mycobacterium smegmatis),
interacts with mycobacterial RNA polymerase (RNAP) and affects rifampicin resistance in …
interacts with mycobacterial RNA polymerase (RNAP) and affects rifampicin resistance in …
[PDF][PDF] of Thesis: Structural Characterization of Proteins
Intrinsically disordered proteins (IDPs) are a class of proteins that lack a fixed three-
dimensional structure and instead exist in a dynamic ensemble of conformations. IDPs are …
dimensional structure and instead exist in a dynamic ensemble of conformations. IDPs are …