Carvacrol reduces mercuric chloride-induced testicular toxicity by regulating oxidative stress, inflammation, apoptosis, autophagy, and histopathological changes

H Şimşek, C Gür, S Küçükler, M İleritürk… - … Trace Element Research, 2024 - Springer
Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR)
is a flavonoid found naturally in plants and has many biological and pharmacological …

Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.

SA Akarsu, C Gür, M İleritürk, N Akaras… - Journal of Trace …, 2023 - Elsevier
Background Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the
most common of these heavy metals. In this study, it was aimed at investigating the effects of …

The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage …

NA Kankılıç, H Şimşek, N Akaras, C Gür… - Food and Chemical …, 2024 - Elsevier
Aim Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be
approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is …

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

SÇ Tuncer, SA Akarsu, S Küçükler, C Gür… - Environmental …, 2023 - Wiley Online Library
In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on
oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular …

The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach

N Akaras, M Ileriturk, C Gur, S Kucukler, M Oz… - … Science and Pollution …, 2023 - Springer
This study aimed to determine the potential protective effects of chrysin (CHR) on
experimental cadmium (Cd)-induced lung toxicity in rats. To this end, rats were divided into …

Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and …

NA Kankılıç, H Şimşek, N Akaras, C Gür… - … of Biochemical and …, 2024 - Wiley Online Library
Antimicrobial agent resistance has become a growing health issue across the world. Colistin
(COL) is one of the drugs used in the treatment of multidrug‐resistant bacteria resulting in …

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

M Ileriturk, D Ileriturk, O Kandemir… - … of biochemical and …, 2024 - Wiley Online Library
Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases.
Naringin (4′, 5, 7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of …

The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 …

S Gencer, C Gür, M İleritürk, S Küçükler… - … of biochemical and …, 2024 - Wiley Online Library
Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in
the body is the liver. Carvacrol is a natural phytocompound that stands out with its …

Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK …

NA Kankılıç, S Küçükler, C Gür… - … of biochemical and …, 2024 - Wiley Online Library
Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic
effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural …

Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach

H Şimşek, S Küçükler, C Gür, M İleritürk… - Iranian Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Objective (s): Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a
flavonoid with many biological properties found naturally in honey and plants. This study …