Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more
somatic mutations/copy number alterations that can expand with time and under positive …

Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and
cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune …

Gene mutations independent of BCR:: ABL1 have been identified in newly diagnosed
patients with chronic myeloid leukemia (CML) in chronic phase, whereby mutations in …

Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs)
drive clonal hematopoiesis (CH). While some CH drivers have been identified, the …

DNMT3A mutations play a prominent role in clonal hematopoiesis and myeloid neoplasms
with arginine (R) 882 as a hotspot, however the clinical implications of R882 vs. non-R882 …

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of
hematopoietic lineage that carry acquired somatic alterations associated with hematologic …

Clonal hematopoiesis (CH) is an age-related condition driven by stem and progenitor cells
harboring recurrent mutations linked to myeloid neoplasms. Currently, potential effects on …