Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Reactive oxygen species in the regulation of synaptic plasticity and memory

CA Massaad, E Klann - Antioxidants & redox signaling, 2011 - liebertpub.com
The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

Terpene compounds in nature: a review of their potential antioxidant activity

E Gonzalez-Burgos… - Current medicinal …, 2012 - ingentaconnect.com
Reactive Oxygen Species are involved in the pathological development of many important
human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes …

[HTML][HTML] A review for the pharmacological effect of lycopene in central nervous system disorders

D Chen, C Huang, Z Chen - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes,
papayas, and watermelons. Previous studies have shown that lycopene can exert …

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

A Kaulmann, T Bohn - Nutrition research, 2014 - Elsevier
Several epidemiologic studies have shown that diets rich in fruits and vegetables reduce the
risk of develo** several chronic diseases, such as type 2 diabetes, atherosclerosis, and …

Review on rosmarinic acid extraction, fractionation and its anti-diabetic potential

YL Ngo, CH Lau, LS Chua - Food and Chemical Toxicology, 2018 - Elsevier
Rosmarinic acid is a bioactive phytochemical that can be found in many herbs as
ethnomedicines. It possesses remarkable pharmacological activities, and thus leading to its …

Lycopene in protection against obesity and diabetes: A mechanistic review

R Zhu, B Chen, Y Bai, T Miao, L Rui, H Zhang… - Pharmacological …, 2020 - Elsevier
Lycopene, a natural pigment that mainly exists in the mature fruit of tomatoes, has gained
increasing attention due to its protective effects against obesity and diabetes. The aim of this …

Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking …

P Taslimi, M Işık, F Türkan, M Durgun… - Journal of …, 2021 - Taylor & Francis
Sulfonamide derivatives exhibit a wide biological activity and can function as potential
medical molecules in the development of a drug. Studies have reported that the compounds …

Synthesis, characterization, and inhibition study of novel substituted phenylureido sulfaguanidine derivatives as α‐glycosidase and cholinesterase inhibitors

S Akocak, P Taslimi, N Lolak, M Işık… - Chemistry & …, 2021 - Wiley Online Library
A series of six N‐carbamimidoyl‐4‐(3‐substituted phenylureido) benzenesulfonamide
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …