Iron metabolism is vital for the survival of both humans and microorganisms. Heme
oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs …

Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In
tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis …

Alveolar macrophages (AMs) are the first cells to be infected during Mycobacterium
tuberculosis (M. tb.) infection. Thus, the AM response to infection is the first of many steps …

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …

Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-
dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …

Significance: Excessive and prolonged proinflammatory responses are associated with
oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such …

Abstract Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting enzymatic step of
heme degradation, producing carbon monoxide, biliverdin, and free iron. Most iron is …

The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognized to play a
crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we …

Rationale: Our current understanding of tuberculosis (TB) pathophysiology is limited by a
reliance on animal models, the paucity of human TB lung tissue, and traditional …