Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

Antitarget, anti-SARS-CoV-2 leads, drugs, and the drug discovery–genetics alliance perspective

C Pozzi, A Vanet, V Francesconi… - Journal of Medicinal …, 2023 - ACS Publications
The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

L Wu, A Zheng, Y Tang, Y Chai, J Chen… - Science China Life …, 2023 - Springer
Coronaviruses (CoVs) have brought serious threats to humans, particularly severe acute
respiratory syndrome Coronavirus 2 (SARS-CoV-2), which continually evolves into multiple …

Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity

S Mougari, V Favède, C Predella, O Reynard… - Communications …, 2025 - nature.com
We have assessed antiviral activity and induction of protective immunity of fusion-inhibitory
lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike …

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

K Yang, C Wang, AJB Kreutzberger… - Proceedings of the …, 2023 - National Acad Sciences
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
introduced a relatively large number of mutations, including three mutations in the highly …

Cholesterol and Ceramide Facilitate Membrane Fusion Mediated by the Fusion Peptide of the SARS-CoV-2 Spike Protein

K Niort, J Dancourt, E Boedec, Z Al Amir Dache… - ACS …, 2023 - ACS Publications
SARS-CoV-2 entry into host cells is mediated by the Spike (S) protein of the viral envelope.
The S protein is composed of two subunits: S1 that induces binding to the host cell via its …

[HTML][HTML] Design and characterization of novel SARS-CoV-2 fusion inhibitors with N-terminally extended HR2 peptides

Y Hu, Y Zhu, Y Yu, N Liu, X Ju, Q Ding, Y He - Antiviral Research, 2023 - Elsevier
Abstract Development of potent and broad-spectrum antivirals against SARS-CoV-2 remains
one of top priorities, especially in the case of that current vaccines cannot effectively prevent …

[HTML][HTML] SARS-CoV-2 inhibitory activity of a short peptide derived from internal fusion peptide of S2 subunit of spike glycoprotein

MA Stincarelli, M Quagliata, A Di Santo, L Pacini… - Virus Research, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a great concern
in human population. To fight coronavirus emergence, we have dissected the conserved …

Ultrafast universal fabrication of configurable porous silicone-based elastomers by Joule heating chemistry

F Xu, H Zhang, H Liu, W Han, Z Nie… - Proceedings of the …, 2024 - National Acad Sciences
Silicone-based elastomers (SEs) have been extensively applied in numerous cutting-edge
areas, including flexible electronics, biomedicine, 5G smart devices, mechanics, optics, soft …