T Follicular Helper Cell Heterogeneity
T follicular helper (Tfh) cells specialize in hel** B cells and are therefore critical
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
Protective fibroblastic niches in secondary lymphoid organs
A De Martin, Y Stanossek, NB Pikor… - Journal of Experimental …, 2023 - rupress.org
Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA
vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here …
vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here …
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma
Antibodies are produced when naive B cells differentiate into plasma cells within germinal
centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on effective …
centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on effective …
Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging‐related diseases
T **a, Y Zhou, J An, Z Cui, X Zhong, T Cui, B Lv… - Aging …, 2024 - Wiley Online Library
CD4+ T cells play a notable role in immune protection at different stages of life. During
aging, the interaction between the body's internal and external environment and CD4+ T …
aging, the interaction between the body's internal and external environment and CD4+ T …
[HTML][HTML] Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
MA Linterman - Seminars in Immunology, 2023 - Elsevier
Vaccination is an excellent strategy to limit the morbidity and mortality associated with
infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by …
infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by …
Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization
Summary mRNA vaccines have proven to be pivotal in the fight against COVID-19. A
recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially …
recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially …
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …
system is no exception to that inevitable principle. Of all the age-related changes in the …
[HTML][HTML] Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Vaccines are among the greatest inventions in medicine, leading to the elimination or
control of numerous diseases, including smallpox, polio, measles, rubella, and, most …
control of numerous diseases, including smallpox, polio, measles, rubella, and, most …
The follicular dendritic cell: At the germinal center of autoimmunity?
Autoimmune diseases strain healthcare systems worldwide as their incidence rises, and
current treatments put patients at risk for infections. An increased understanding of …
current treatments put patients at risk for infections. An increased understanding of …