Nonribosomal peptide synthesis—principles and prospects

RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Natural product and natural product derived drugs in clinical trials

MS Butler, AAB Robertson, MA Cooper - Natural product reports, 2014 - pubs.rsc.org
Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

Marine natural products

JW Blunt, BR Copp, RA Keyzers, MHG Munro… - Natural Product …, 2015 - pubs.rsc.org
Covering: 2013. Previous review: Nat. Prod. Rep., 2014, 31, 160–258 This review covers the
literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for …

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

LV Flórez, PHW Biedermann, T Engl… - Natural Product …, 2015 - pubs.rsc.org
Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …

Marine natural products

JW Blunt, BR Copp, RA Keyzers, MHG Munro… - Natural product …, 2014 - pubs.rsc.org
Covering: 2012. Previous review: Nat. Prod. Rep., 2013, 30, 237–323. This review covers
the literature published in 2012 for marine natural products, with 1035 citations (673 for the …

Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds

CT Walsh, RV O'Brien, C Khosla - … Chemie International Edition, 2013 - Wiley Online Library
Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

Marine biosurfactants: biosynthesis, structural diversity and biotechnological applications

S Kubicki, A Bollinger, N Katzke, KE Jaeger… - Marine drugs, 2019 - mdpi.com
Biosurfactants are amphiphilic secondary metabolites produced by microorganisms. Marine
bacteria have recently emerged as a rich source for these natural products which exhibit …

Marine drugs: Biology, pipelines, current and future prospects for production

N Papon, BR Copp, V Courdavault - Biotechnology Advances, 2022 - Elsevier
The marine environment is a huge reservoir of biodiversity and represents an excellent
source of chemical compounds, some of which have large economical values. In the urgent …

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

DJ Newman, GM Cragg - Marine drugs, 2014 - mdpi.com
The marine habitat has produced a significant number of very potent marine-derived agents
that have the potential to inhibit the growth of human tumor cells in vitro and, in a number of …

Biomaterials and bioactive natural products from marine invertebrates: From basic research to innovative applications

G Romano, M Almeida, A Varela Coelho, A Cutignano… - Marine Drugs, 2022 - mdpi.com
Aquatic invertebrates are a major source of biomaterials and bioactive natural products that
can find applications as pharmaceutics, nutraceutics, cosmetics, antibiotics, antifouling …