Arthropod-borne viruses, referred to collectively as arboviruses, infect millions of people
worldwide each year and have the potential to cause severe disease. They are …

Highlights•Salivary genes are highly divergent and evolve under strong selective
pressure.•Gene duplication played a major role in evolution of novel salivary …

T-cell activation and expansion in the tumor microenvironment (TME) are critical for
antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell …

Salivary complement inhibitors occur in many of the blood feeding arthropod species
responsible for transmission of pathogens. During feeding, these inhibitors prevent the …

Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect
protein that directly attracts mammalian innate cells such as neutrophils has not been …

Complement is a network of soluble and cell surface-associated proteins that gives rise to a
self-amplifying, yet tightly regulated system with fundamental roles in immune surveillance …

Lutzomyia longipalpis is the most important vector of Leishmania infantum, the etiological
agent of visceral leishmaniasis (VL) in the New World. It is a permissive vector susceptible to …

Leishmaniases are a group of vector-borne parasitic diseases transmitted through the
infected sand flies. Leishmania parasites are inoculated into the host skin along with sand fly …

The habit of blood feeding evolved independently in many insect orders of families. Sand
flies and mosquitoes belong to separate lineages of blood-feeding Diptera and are thus …

The complement and coagulation systems closely interact with each other. These
interactions are believed to contribute to the proinflammatory and prothrombotic …