Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Prion diseases are fatal neurodegenerative disorders that affect both humans and animals.
The rapid clinical progression, change in protein conformation, cross-species transmission …

Lithium is used for several decades to treat manic‐depressive illness (bipolar affective
disorder). Recently, it was found that lithium induces autophagy, thereby promoting the …

A variety of physiological functions, not only restricted to the nervous system, are discussed
for the cellular prion protein (PrPC). A prominent, non-physiological property of PrPC is the …

Neurites of neurons under acute or chronic stress form bundles of filaments (rods)
containing 1∶ 1 cofilin∶ actin, which impair transport and synaptic function. Rods contain …

Nearly 50% of individuals with long-term HIV infection are affected by the onset of
progressive HIV-associated neurocognitive disorders (HAND). HIV infiltrates the central …

Mature neurotrophic factors and their propeptides play key roles ranging from the regulation
of neuronal growth and differentiation to prominent participation in neuronal survival and …

The Prion protein (PrPc) involvement in some neurodegenerative diseases is well assessed
although its “normal” biological role is not completely understood. It is known that PrPC can …

The conversion of cellular prion protein (PrPc), a GPI-anchored protein, into a protease-K-
resistant and infective form (generally termed PrPsc) is mainly responsible for Transmissible …

Several studies have indicated that certain misfolded amyloids composed of tau, β-amyloid
or α-synuclein can be transferred from cell to cell, suggesting the contribution of …