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Advanced tandem mass spectrometry in metabolomics and lipidomics—methods and applications
S Heiles - Analytical and Bioanalytical Chemistry, 2021 - Springer
Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
Determination of the compound class and functional groups in protonated analytes via diagnostic gas‐phase ion‐molecule reactions
Diagnostic gas‐phase ion‐molecule reactions serve as a powerful alternative to collision‐
activated dissociation for the structural elucidation of analytes when using tandem mass …
activated dissociation for the structural elucidation of analytes when using tandem mass …
Effects of residual water in a linear quadrupole ion trap on the protonation sites of 4-aminobenzoic acid
In solution, the most basic site in 4-aminobenzoic acid is the amino nitrogen, while the
carboxylic acid oxygen is the most basic site in the gas phase. However, the protonation site …
carboxylic acid oxygen is the most basic site in the gas phase. However, the protonation site …
Characterization of protonated substituted Ureas by using diagnostic gas-phase ion-molecule reactions followed by collision-activated dissociation in tandem mass …
Substituted ureas correspond to a class of organic compounds commonly used in
agricultural and chemical fields. However, distinguishing between different ureas and …
agricultural and chemical fields. However, distinguishing between different ureas and …
Factors affecting the limit of detection for HPLC/tandem mass spectrometry experiments based on gas-phase ion–molecule reactions
Diagnostic and predictable gas-phase ion–molecule reactions have emerged as a potential
alternative to collision-activated dissociation in tandem mass spectrometry (MS2) …
alternative to collision-activated dissociation in tandem mass spectrometry (MS2) …
Oxidative degradation in pharmaceuticals: mechanism and stabilization of a spray-dried amorphous drug–a case study
Drug formulations such as spray drying are often required to improve the physicochemical
properties and bioavailability of hydrophobic drugs. However, excipients often carry …
properties and bioavailability of hydrophobic drugs. However, excipients often carry …
Ion‐molecule reactions of mass‐selected ions
K Parker, NE Bollis, V Ryzhov - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Gas‐phase reactions of mass‐selected ions with neutrals covers a very broad area of
fundamental and applied mass spectrometry (MS). Oftentimes, ion‐molecule reactions (IMR) …
fundamental and applied mass spectrometry (MS). Oftentimes, ion‐molecule reactions (IMR) …
Integration of a multichannel pulsed-valve inlet system to a linear quadrupole ion trap mass spectrometer for the rapid consecutive introduction of nine reagents for …
Gas-phase ion/molecule reactions have been used extensively for the structural elucidation
of organic compounds in tandem mass spectrometry. Reagents for ion/molecule reactions …
of organic compounds in tandem mass spectrometry. Reagents for ion/molecule reactions …
Effects of Analyte Concentration on the Protonation Sites of 4-Aminobenzoic Acid upon Atmospheric Pressure Chemical Ionization As Revealed by Gas-Phase Ion …
R Kumar, HI Kenttämaa - Journal of the American Society for …, 2020 - ACS Publications
The most basic site of 4-aminobenzoic acid in aqueous solution is the amino nitrogen, while
the carbonyl oxygen is calculated to be the most basic site in the gas phase. However, the …
the carbonyl oxygen is calculated to be the most basic site in the gas phase. However, the …
A fixed‐charge model of the N‐protomer of 4‐aminobenzoic acid to facilitate the study of the unimolecular and bimolecular chemistry of its “neutral” carboxylic acid …
Rationale There are a growing number of examples of protomers formed via electrospray
ionization (ESI) that do not fragment under mobile proton conditions, giving rise to distinct …
ionization (ESI) that do not fragment under mobile proton conditions, giving rise to distinct …