Significance: Cellular redox processes are highly interconnected, yet not in equilibrium, and
governed by a wide range of biochemical parameters. Technological advances continue …

Highlights•Low oxygen tensions are present throughout the gastrointestinal tract.•Although
Clostridioides difficile is considered as obligate anaerobe, this bacterium can tolerate low …

Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies
on stored resources and is reactivated to drive germination when the external conditions are …

Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal
growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species …

Redox proteomics is a field of proteomics that is concerned with the characterization of the
oxidation state of proteins to gain information about their modulated structure, function …

Clostridioides difficile is the major pathogen causing diarrhea following antibiotic treatment.
It is considered to be a strictly anaerobic bacterium, however, previous studies have shown …

Clostridioides difficile is an intestinal human pathogen that uses the opportunity of a
depleted microbiota to cause an infection. It is known, that the composition of the intestinal …

Nucleoredoxin (Nrx) is an oxidoreductase of the thioredoxin family of proteins. It was shown
to act as a signal transducer in some pathways; however, so far, no comprehensive analysis …

The human pathogen Clostridioides difficile has evolved into the leading cause of
nosocomial diarrhea. The bacterium is capable of spore formation, which even allows …

Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB
by covalently binding to their cysteine protease domains. It was suggested that ebselen …