Methane is one of the most important greenhouse gases on Earth and holds an important
place in the global carbon cycle. Archaea are the only organisms that use methanogenesis …

Plasmids are universally present in bacteria and play key roles in the dissemination of
genes such as antibiotic resistance determinants. Major concepts in Plasmid Biology derive …

Large serine recombinases (LSRs) are DNA integrases that facilitate the site-specific
integration of mobile genetic elements into bacterial genomes. Only a few LSRs, such as …

Bacteria and archaea have developed multiple antiviral mechanisms, and genomic
evidence indicates that several of these antiviral systems co-occur in the same strain. Here …

Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …

A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …

Predicting bacteriophage infection of specific bacterial strains promises advancements in
phage therapy and microbial ecology. Whether the dynamics of well-established phage …

CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against …

To provide protection against viral infection and limit the uptake of mobile genetic elements,
bacteria and archaea have evolved many diverse defence systems. The discovery and …

The human gut microbiome plays an important role in health, but its archaeal diversity
remains largely unexplored. In the present study, we report the analysis of 1,167 …